If you want to connect to the mainnet, you need to have a full blockchain node. You can use Geth or Parity. But there is other way, which is using Infura. Go to Infura website. Register an account then create a new project. You would get project ID and project secret.
Your settings.py in Mamba project must look like this:
networks = {
"development": {
"mode": "Infura",
"scheme": "https",
"endpoints": "mainnet"
}
}
infura_settings = {
"project_id": "FILL_IT_WITH_PROJECT_ID",
"project_secret": "FILL_IT_WITH_PROJECT_SECRET",
}
"scheme" can be "https" or "wss". "endpoints" can be "mainnet" or "kovan" or "rinkeby" or other network. Don't forget to fill "project_id" and "project_secret" with the values you got from Infura website.